75 kg,CrCl 80 → 负荷 1500–1875 mg,维持 1125–1500 mg q12h 负荷 20–25 mg/kg = 1500–1875 mg;维持 15–20 mg/kg = 1125–1500 mg。CrCl 80 → q12h。首选 AUC₀₋₂₄/MIC 400–600,谷浓度 15–20 mg/L 为次要。{"result":"Loading 1500–1875 mg; maintenance 1125–1500 mg every 12 h. Primary target: AUC₀₋₂₄/MIC 400–600 mg·h/L; trough 15–20 mg/L is secondary.","metadata":{"input":{"weight":75,"crcl":80,"trough":null},"result":{"loadingDoseRange":"1500–1875 mg","loadingDoseLow":1500,"loadingDoseHigh":1875,"maintenanceDoseRange":"1125–1500 mg","maintenanceDoseLow":1125,"maintenanceDoseHigh":1500,"empiricInterval":"q12 h","intervalNote":"Common empiric interval.","monitoring":{"primaryTarget":"AUC₀₋₂₄/MIC 400–600 mg·h/L within first 24–48 h","troughTarget":"15–20 mg/L (secondary, only when AUC unavailable)"},"method":"2020 ASHP/IDSA empiric weight-based dosing","model":"Rybak MJ et al. Am J Health-Syst Pharm 2020;77:835-864. Empiric start only; individualize by AUC. Not medical advice."}}}
肥胖 120 kg,CrCl 55,谷浓度 17 → 负荷 2400–3000 mg,谷浓度达标 负荷 20–25 mg/kg = 2400–3000 mg;维持 15–20 mg/kg = 1800–2400 mg。CrCl 55 → q12h。谷浓度 17 → 达标(次要目标)。{"result":"Loading 2400–3000 mg; maintenance 1800–2400 mg every 12 h. Measured trough 17 mg/L: Therapeutic (secondary target). Primary target: AUC₀₋₂₄/MIC 400–600 mg·h/L.","metadata":{"input":{"weight":120,"crcl":55,"trough":17},"result":{"loadingDoseRange":"2400–3000 mg","loadingDoseLow":2400,"loadingDoseHigh":3000,"maintenanceDoseRange":"1800–2400 mg","maintenanceDoseLow":1800,"maintenanceDoseHigh":2400,"empiricInterval":"q12 h","intervalNote":"Common empiric interval.","troughAssessment":{"trough":17,"status":"Therapeutic (secondary target)","action":"Targets serious MRSA trough range; AUC monitoring preferred per 2020 guideline."},"monitoring":{"primaryTarget":"AUC₀₋₂₄/MIC 400–600 mg·h/L within first 24–48 h","troughTarget":"15–20 mg/L (secondary, only when AUC unavailable)"},"method":"2020 ASHP/IDSA empiric weight-based dosing","model":"Rybak MJ et al. Am J Health-Syst Pharm 2020;77:835-864. Empiric start only; individualize by AUC. Not medical advice."}}}