Health

Vancomycin Empiric Dosing Calculator (2020 ASHP/IDSA)

Empiric starting dosing for vancomycin per the 2020 ASHP/IDSA/PIDS/SIDP consensus guideline. Loading dose: 20–25 mg/kg actual body weight (obesity cap 3000 mg). Maintenance dose: 15–20 mg/kg actual body weight every 8–12 h. Optional creatinine clearance (CrCl) input suggests an empiric dosing interval (≥90 → q8h, 50–89 → q12h, 30–49 → q18–24h, 10–29 → q24h, <10 → q24–48h). Optional measured trough is classified against the SECONDARY trough target of 15–20 mg/L. The 2020 guideline shifted the primary monitoring target to AUC₀₋₂₄/MIC = 400–600 mg·h/L (within first 24–48 h); trough-only monitoring is no longer recommended as primary. Derived from Rybak MJ et al., Am J Health-Syst Pharm 2020. Empiric start doses ONLY — individualize by AUC-guided Bayesian monitoring. Not medical advice.