CrCl 45 mL/min → 轻度损害（考虑调整） CrCl 45 处于轻度范围（30–59）。对窄治疗窗的肾排泄药物考虑减量或延长间隔。{"result":"CrCl 45 mL/min — Mild renal impairment (CrCl 30–59 mL/min). Consider dose reduction or interval extension.","metadata":{"input":{"crcl":45,"onDialysis":false},"result":{"category":"Mild renal impairment","crClRange":"CrCl 30–59 mL/min","generalGuidance":"Consider dose reduction or interval extension for renally cleared drugs with a narrow therapeutic index.","intervalStrategy":"Consider extending interval (e.g., q12h → q18–24h) for concentration-dependent drugs.","doseStrategy":"Or reduce dose by ~25–50% while keeping the interval for time-dependent drugs.","onDialysis":false,"method":"FDA/KDIGO renal-function categories","model":"FDA PK Guidance; KDIGO Drug Dosing Consensus; NIDDK. Does not replace the drug label. Not medical advice."}}}
CrCl 12 mL/min，透析中 → 重度损害 + 透析后补充 CrCl 12 属重度（<15）：需显著减量，许多药物仅透析后给予。透析标志提醒按药品说明书在透析后补充肾排泄药物。{"result":"CrCl 12 mL/min — Severe renal impairment (CrCl < 15 mL/min). Significant reduction required; on dialysis: supplement renally cleared drugs post-dialysis per label.","metadata":{"input":{"crcl":12,"onDialysis":true},"result":{"category":"Severe renal impairment","crClRange":"CrCl < 15 mL/min","generalGuidance":"Significant dose reduction required; many drugs are contraindicated or given post-dialysis only. Individualize by drug-level monitoring where available.","intervalStrategy":"Markedly extended interval (often q24–48h or post-dialysis) for concentration-dependent drugs.","doseStrategy":"Substantial dose reduction (often ≥75%) or avoid; consult the specific drug label.","onDialysis":true,"dialysisNote":"Renally cleared drugs often require post-dialysis supplementation (drug-specific). Consult the drug label.","method":"FDA/KDIGO renal-function categories","model":"FDA PK Guidance; KDIGO Drug Dosing Consensus; NIDDK. Does not replace the drug label. Not medical advice."}}}