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Dialysis Dose Kt/V Calculator (Daugirdas 2nd Gen.)

· Last updated：2026-08-05

This tool is for informational purposes only and does not constitute medical, financial, or legal advice; consult a qualified professional for advice.

Estimate single-pool Kt/V (spKt/V) for a hemodialysis session with the Daugirdas second-generation formula: Kt/V = −ln(R − 0.008·t) + (4 − 3.5·R) × UF / W, where R = Post-BUN/Pre-BUN, t = treatment time (h), UF = ultrafiltration volume (kg), W = post-dialysis weight (kg). The first term captures urea removal and generation; the second corrects for volume contraction. KDOQI target: spKt/V ≥1.2 per session (minimum delivered dose) for conventional thrice-weekly hemodialysis, target ~1.4. Requires post-dialysis BUN drawn by slow-flow/stop-pump technique. Derived from Daugirdas JT, J Am Soc Nephrol 1993. Valid for intermittent hemodialysis; not for peritoneal dialysis or CRRT/SLED. Not medical advice.

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Tool usage guide

Learn when to use this tool, what it supports, and how real users apply it.

Key facts

Category
Health
Input types
number
Output type
json
Sample coverage
4
API ready
Yes

Overview

Estimate single-pool Kt/V (spKt/V) for an intermittent hemodialysis session using the Daugirdas second-generation formula. Enter pre- and post-dialysis BUN, treatment time, ultrafiltration volume, and post-dialysis weight to receive the Kt/V value, BUN ratio, and a status against the 1.2 minimum reference.

When to use

  • Estimate delivered dialysis dose for a conventional intermittent hemodialysis session.
  • Review how BUN reduction, treatment time, ultrafiltration, and post-dialysis weight affect spKt/V.
  • Check whether a calculated session reaches the KDOQI minimum reference of 1.2.

How it works

  1. 1Enter positive pre-dialysis and post-dialysis BUN values, with post-dialysis BUN lower than pre-dialysis BUN.
  2. 2Enter treatment time in hours, ultrafiltration volume in kilograms, and post-dialysis weight in kilograms.
  3. 3The calculator computes R as post-dialysis BUN divided by pre-dialysis BUN and applies the Daugirdas second-generation formula.
  4. 4The JSON result includes Kt/V, ratio R, status, method, and a note about the 1.2 minimum reference.

Use cases

  • Nephrology teams can estimate the delivered spKt/V for individual hemodialysis sessions.
  • Dialysis educators can demonstrate the relationship between BUN values, treatment time, ultrafiltration, and post-dialysis weight.
  • Clinical reviewers can compare calculated results with the KDOQI minimum reference and target range.

Examples

1. Four-hour session reaching the minimum reference

Dialysis clinician

Background

A hemodialysis session has a pre-dialysis BUN of 90 mg/dL and a post-dialysis BUN of 30 mg/dL.

Problem

Estimate the delivered single-pool Kt/V and determine whether it reaches the 1.2 minimum reference.

How to use

Enter preBun 90, postBun 30, treatmentTime 4, ultrafiltration 2, postWeight 70, and decimalPlaces 4.

{"preBun":90,"postBun":30,"treatmentTime":4,"ultrafiltration":2,"postWeight":70,"decimalPlaces":4}

Outcome

The calculator returns Kt/V = 1.2805, with R = 0.3333 and status indicating that the 1.2 minimum is met.

2. Shorter session with higher ultrafiltration

Dialysis educator

Background

A session uses a pre-dialysis BUN of 100 mg/dL, a post-dialysis BUN of 35 mg/dL, 3.5 hours of treatment, and 3 kg of ultrafiltration.

Problem

Calculate spKt/V while accounting for the post-dialysis weight of 80 kg.

How to use

Enter preBun 100, postBun 35, treatmentTime 3.5, ultrafiltration 3, postWeight 80, and decimalPlaces 4.

FAQ

What does this calculator estimate?

It estimates single-pool Kt/V (spKt/V) for an intermittent hemodialysis session.

Which formula does it use?

It uses the Daugirdas second-generation formula: −ln(R − 0.008·t) + (4 − 3.5·R)·UF/W.

What inputs are required?

Pre- and post-dialysis BUN, treatment time, ultrafiltration volume, and post-dialysis weight are required.

How should post-dialysis BUN be collected?

Use a slow-flow or stop-pump collection technique, as specified in the tool description.

Does this calculator apply to peritoneal dialysis or CRRT?

No. It is intended for intermittent hemodialysis and not for peritoneal dialysis, CRRT, or SLED.

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{"preBun":100,"postBun":35,"treatmentTime":3.5,"ultrafiltration":3,"postWeight":80,"decimalPlaces":4}

Outcome

The calculator returns Kt/V = 1.2373, with R = 0.35 and status indicating that the 1.2 minimum is met.