Red Cell Distribution Width (RDW) Analyzer

Analyze Mean Platelet Volume (MPV) in fL, an index of platelet production kinetics. Reference range ≈ 7.5–11.5 fL (lab- and method-dependent). Low MPV (< 7.5 fL, small old platelets) indicates suppressed marrow production (aplastic anemia, chemotherapy/radiation, recent platelet transfusion, iron-deficiency regeneration, Wiskott-Aldrich). High MPV (> 11.5 fL, large young platelets) indicates peripheral destruction with compensatory turnover or macrothrombocytopenia (immune thrombocytopenia ITP, post-splenectomy, myeloproliferative neoplasms, severe sepsis in recovery, Bernard-Soulier / MYH9, megaloblastic anemia; elevated MPV after acute MI marks platelet activation and adverse prognosis). Optionally enter the platelet count to refine the differential: low platelets + high MPV → peripheral destruction; low + low → underproduction; high + low → reactive thrombocytosis; high + high → myeloproliferative neoplasm. Pre-analytical caveat: platelets swell in EDTA over ~2 h raising MPV, and values are method-dependent (impedance > optical > immuno) — compare within the same lab and analyzer. Derived from Bath 1996, Leader 2012, Vagdatli 2010, and MDCalc. Not medical advice.

Calculate solute-free water clearance (C_H₂O) and electrolyte-free water clearance (eC_H₂O) to differentiate hypo-/hypernatremia. Classic: C_H₂O = V·(1 − U_osm/P_osm); positive = dilute urine excreting free water (diabetes insipidus, polydipsia, water-load recovery), negative = concentrated urine conserving free water (dehydration, SIADH). Electrolyte-free: eC_H₂O = V·(1 − (U_Na + U_K)/P_Na), which better predicts the direction of serum sodium change — a negative eC_H₂O means the urine is electrolyte-free-water-rich and tends to raise serum Na⁺, informing IV fluid choice. Optional Na/K inputs enable the electrolyte-free calculation. Derived from Rose, Shimizu 2002 (Nephron), and NephSIM. Point estimate; interpret with full clinical context. Not medical advice.

Calculate the serum Anion Gap (AG) to classify metabolic acidosis. Standard formula AG = Na⁺ − Cl⁻ − HCO₃⁻ (mmol/L), or AG = Na⁺ + K⁺ − Cl⁻ − HCO₃⁻ with optional potassium. A high AG (≈ >12, or >20 with K⁺) indicates accumulation of unmeasured anions (lactic acidosis, ketoacidosis, renal failure, and toxins such as methanol/ethylene glycol, salicylates — mnemonic GOLD-MARK). A normal AG (8–12) during metabolic acidosis points to a hyperchloremic (normal-anion-gap) acidosis: diarrhea, renal tubular acidosis, saline resuscitation. A low AG (<3–6) is usually hypoalbuminemia, also hypercalcemia/hypermagnesemia, lithium, cationic IgG paraproteins, or bromide pseudo-hyperchloraemia. Optional albumin correction AG_corrected = AG + 2.5 × (4.0 − albumin g/dL) avoids missing a high-AG acidosis in hypoalbuminemia. Derived from Kraut CJASN 2007, Figge 1998, and MDCalc. Interpret with blood gas and full clinical context. Not medical advice.

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