种群瓶颈效应模拟器（杂合度衰减）

POST http://127.0.0.1:3003/zh/api/tools/bottleneck-effect-simulator

{
  "mcpServers": {
    "elysiatools-bottleneck-effect-simulator": {
      "name": "bottleneck-effect-simulator",
      "description": "模拟种群瓶颈后的期望杂合度损失（确定性期望）。理想 Wright-Fisher 漂变下每代 H_{t+1} = H_t(1 − 1/(2N))，故 H_final = H₀(1−1/2Nb)^t × (1−1/2Nr)^g；调和平均有效种群大小 Ne = (t+g)/(t/Nb + g/Nr) 由最小瓶颈主导；相对基础群体的累积近交系数 F = 1 − H_final/H₀。对频率 p 的目标等位基因，单代瓶颈存活概率 = 1 − (1−p)^(2Nb)，稀有等位基因最先丢失。经典案例：北象海豹（1890 年代约 20 只幸存 → 近零变异）、猎豹、夏威夷雁、欧洲野牛、平格拉普环礁。来源：Wright 1931、Nei et al. 1975、Hartl & Clark 2007、StatPearls。仅供教学用途。",
      "baseUrl": "http://127.0.0.1:3003/mcp/sse?toolId=bottleneck-effect-simulator",
      "command": "",
      "args": [],
      "env": {},
      "isActive": true,
      "type": "sse"
    }
  }
}

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/list"
}

{
  "jsonrpc": "2.0",
  "id": 2,
  "method": "tools/call",
  "params": {
    "name": "bottleneck-effect-simulator",
    "arguments": {
  "initialHeterozygosity": 0.5,
  "bottleneckSize": 20,
  "bottleneckGenerations": 5,
  "recoverySize": 2000,
  "recoveryGenerations": 10,
  "alleleFrequency": 0.1,
  "decimalPlaces": 4
}
  }
}