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Renal Drug Dose Adjustment Helper

Categorize renal function from creatinine clearance (CrCl) and provide FDA/KDIGO-aligned dosing guidance: Normal (CrCl ≥60) → standard dosing; Mild (30–59) → consider dose reduction or interval extension; Moderate (15–29) → reduction and/or extension typically required; Severe (<15) → significant reduction, many drugs contraindicated or post-dialysis only. Outlines two adjustment strategies: (A) interval extension for concentration-dependent drugs (aminoglycosides, vancomycin), (B) dose reduction for time-dependent drugs (β-lactams). Dialysis toggle flags the need for post-dialysis supplementation per the specific drug label. Derived from FDA Pharmacokinetics Guidance, the KDIGO Drug Dosing Consensus, and NIDDK guidance. This tool does NOT replace the FDA-approved package insert for any specific drug. Not medical advice.