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Mean Platelet Volume (MPV) Analyzer Analyze Mean Platelet Volume (MPV) in fL, an index of platelet production kinetics. Reference range ≈ 7.5–11.5 fL (lab- and method-dependent). Low MPV (< 7.5 fL, small old platelets) indicates suppressed marrow production (aplastic anemia, chemotherapy/radiation, recent platelet transfusion, iron-deficiency regeneration, Wiskott-Aldrich). High MPV (> 11.5 fL, large young platelets) indicates peripheral destruction with compensatory turnover or macrothrombocytopenia (immune thrombocytopenia ITP, post-splenectomy, myeloproliferative neoplasms, severe sepsis in recovery, Bernard-Soulier / MYH9, megaloblastic anemia; elevated MPV after acute MI marks platelet activation and adverse prognosis). Optionally enter the platelet count to refine the differential: low platelets + high MPV → peripheral destruction; low + low → underproduction; high + low → reactive thrombocytosis; high + high → myeloproliferative neoplasm. Pre-analytical caveat: platelets swell in EDTA over ~2 h raising MPV, and values are method-dependent (impedance > optical > immuno) — compare within the same lab and analyzer. Derived from Bath 1996, Leader 2012, Vagdatli 2010, and MDCalc. Not medical advice.