Calculate glucose/amino-acid/lipid delivery (grams and kcal), total and non-protein calories, the non-protein kcal:g nitrogen ratio and per-kg values from a parenteral nutrition prescription. Energy densities: dextrose 3.4 kcal/g, AA 4.0 kcal/g, lipid 20% ≈ 2.0 kcal/mL. Targets (ASPEN/ESPEN): 20–30 kcal/kg/day, protein 1.0–1.5 g/kg/day. This is a prescription-analysis aid, not a compounding recipe. Derived from ASPEN 2016, ESPEN 2019, McClave 2016, Mirtallo 2004. Not medical advice.
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Tool usage guide
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Key facts
Category
Health
Input types
number, select
Output type
json
Sample coverage
4
API ready
Yes
Overview
The TPN Macronutrient Calculator analyzes a parenteral nutrition prescription using patient weight, dextrose and amino-acid concentrations and volumes, lipid emulsion selection, and lipid volume. It estimates macronutrient grams, calories, total and non-protein calories, nitrogen-related ratios, and per-kilogram values. This is a prescription-analysis aid, not a compounding recipe or medical advice.
When to use
Review the calorie and protein contribution of a proposed TPN prescription.
Compare dextrose, amino-acid, and lipid delivery on a per-kilogram basis.
Check total calories, non-protein calories, and the non-protein kcal:g nitrogen ratio.
How it works
1Enter the patient weight in kilograms.
2Enter the dextrose and amino-acid concentrations and total volumes.
3Select the lipid emulsion concentration and enter its total volume.
4The calculator estimates grams, kcal, total and non-protein calories, nitrogen-related values, ratios, and per-kilogram results.
Use cases
Clinical nutrition review of adult parenteral nutrition prescriptions.
Pharmacy and nutrition-support checks of macronutrient and calorie delivery.
Education on how dextrose, amino acids, lipids, and patient weight affect TPN calculations.
Examples
1. Standard adult TPN review
Nutrition-support clinician
Background
A clinician is reviewing a prescription for a 70 kg adult containing D25W, amino-acid solution, and 20% lipid emulsion.
Problem
Estimate the macronutrient grams, calorie contribution, total calories, and values per kilogram.
How to use
Enter a weight of 70 kg, dextrose at 25% with 1000 mL, amino acids at 8.5% with 500 mL, select 20% lipid emulsion, and enter 250 mL of lipid volume.
The calculation estimates 250 g dextrose and 850 kcal, 42.5 g amino acids and 170 kcal, and 50 g lipid and 500 kcal, for about 1520 kcal total and 21.7 kcal/kg.
2. Protein-focused permissive underfeeding review
Critical-care dietitian
Background
An 80 kg patient has a lower-calorie prescription with higher amino-acid delivery and a smaller lipid volume.
Problem
Quantify the prescription's protein and calorie profile and assess its non-protein calorie-to-nitrogen balance.
How to use
FAQ
What inputs does the calculator require?
It requires patient weight, dextrose concentration and volume, amino-acid concentration and volume, lipid emulsion type, and lipid volume.
Which lipid emulsion concentrations are supported?
The calculator supports 10%, 20%, and 30% lipid emulsions.
How are dextrose calories estimated?
Dextrose is estimated at 3.4 kcal per gram.
How are amino-acid calories estimated?
Amino acids are estimated at 4.0 kcal per gram.
Can this tool be used as a compounding recipe?
No. It analyzes prescription inputs and is not a compounding recipe or a substitute for clinical review.
The calculation estimates 100 g dextrose and 340 kcal, 100 g amino acids and 400 kcal, and 20 g lipid and 200 kcal, for about 940 kcal total and 11.8 kcal/kg, with protein at 1.25 g/kg.