Health

Vancomycin Empiric Dosing Calculator (2020 ASHP/IDSA)

Empiric starting dosing for vancomycin per the 2020 ASHP/IDSA/PIDS/SIDP consensus guideline. Loading dose: 20–25 mg/kg actual body weight (obesity cap 3000 mg). Maintenance dose: 15–20 mg/kg actual body weight every 8–12 h. Optional creatinine clearance (CrCl) input suggests an empiric dosing interval (≥90 → q8h, 50–89 → q12h, 30–49 → q18–24h, 10–29 → q24h, <10 → q24–48h). Optional measured trough is classified against the SECONDARY trough target of 15–20 mg/L. The 2020 guideline shifted the primary monitoring target to AUC₀₋₂₄/MIC = 400–600 mg·h/L (within first 24–48 h); trough-only monitoring is no longer recommended as primary. Derived from Rybak MJ et al., Am J Health-Syst Pharm 2020. Empiric start doses ONLY — individualize by AUC-guided Bayesian monitoring. Not medical advice.

json· JSON resultOpen tool

Quick start

Call this tool from your code in three languages.

cURL

curl -X POST 'http://127.0.0.1:3003/en/api/tools/vancomycin-dosing' \
  -H 'Content-Type: application/json' \
  -d '{"weight":75,"crcl":80,"trough":0,"decimalPlaces":4}'

API reference

Send a POST request with your inputs as JSON. File parameters require a separate upload first.

Endpoint

HTTP

POST http://127.0.0.1:3003/en/api/tools/vancomycin-dosing

Parameters

Name	Type	Required	Description
weight	number	Yes	Actual body weight in kg. Must be positive.
crcl	number	No	Optional CrCl in mL/min. Guides empiric dosing interval. Must be ≥0.
trough	number	No	Optional measured/target trough in mg/L for classification against the secondary trough target.
decimalPlaces	number	No	—

Response format

JSON result

JSON

{
  "key": {...},
  "metadata": {
    "key": "value"
  },
  "error": "Error message (optional)",
  "message": "Notification message (optional)"
}

MCP integration

Add this tool to your Model Context Protocol server so AI agents can list and call it.

Server configuration

Add this block to your MCP client configuration:

mcp.json

{
  "mcpServers": {
    "elysiatools-vancomycin-dosing": {
      "name": "vancomycin-dosing",
      "description": "Empiric starting dosing for vancomycin per the 2020 ASHP/IDSA/PIDS/SIDP consensus guideline. Loading dose: 20–25 mg/kg actual body weight (obesity cap 3000 mg). Maintenance dose: 15–20 mg/kg actual body weight every 8–12 h. Optional creatinine clearance (CrCl) input suggests an empiric dosing interval (≥90 → q8h, 50–89 → q12h, 30–49 → q18–24h, 10–29 → q24h, <10 → q24–48h). Optional measured trough is classified against the SECONDARY trough target of 15–20 mg/L. The 2020 guideline shifted the primary monitoring target to AUC₀₋₂₄/MIC = 400–600 mg·h/L (within first 24–48 h); trough-only monitoring is no longer recommended as primary. Derived from Rybak MJ et al., Am J Health-Syst Pharm 2020. Empiric start doses ONLY — individualize by AUC-guided Bayesian monitoring. Not medical advice.",
      "baseUrl": "http://127.0.0.1:3003/mcp/sse?toolId=vancomycin-dosing",
      "command": "",
      "args": [],
      "env": {},
      "isActive": true,
      "type": "sse"
    }
  }
}

List available tools

After connecting to the SSE endpoint, list the exposed tools:

tools/list

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/list"
}

Call this tool

Invoke the tool by its id, passing arguments built from its parameters:

tools/call

{
  "jsonrpc": "2.0",
  "id": 2,
  "method": "tools/call",
  "params": {
    "name": "vancomycin-dosing",
    "arguments": {
  "weight": 75,
  "crcl": 80,
  "trough": 0,
  "decimalPlaces": 4
}
  }
}

Browse tools Open tool