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Transferrin Saturation (TSAT) Calculator

Calculate Transferrin Saturation (TSAT) = Serum Iron / TIBC × 100% (matching units, µg/dL or µmol/L). Reference range ≈ 20–50% in men and 15–50% in women. TSAT < 20% (or < 15% in premenopausal women) indicates iron deficiency (iron-deficiency anemia from chronic blood loss, inadequate intake, malabsorption), and is highly specific when ferritin is also low. TSAT > 50% (> 45% premenopausal) indicates iron overload or ineffective erythropoiesis: hereditary hemochromatosis, thalassemia major, sideroblastic anemia, repeated transfusions, or excessive iron therapy. Note serum iron has diurnal variation (morning high, evening low) and is shifted by recent iron ingestion, infection/inflammation, and hepatic disease — interpret with ferritin and CRP. Derived from Camaschella Blood 2019, Guyatt 1992, and MDCalc. Not medical advice.

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Quick start

Call this tool from your code in three languages.

cURL
curl -X POST 'https://api.elysiatools.com/en/api/tools/transferrin-saturation' \
  -H 'Content-Type: application/json' \
  -d '{"serumIron":30,"tibc":420,"decimalPlaces":1}'

API reference

Send a POST request with your inputs as JSON. File parameters require a separate upload first.

Endpoint

HTTP
POST https://api.elysiatools.com/en/api/tools/transferrin-saturation

Parameters

NameTypeRequiredDescription
serumIronnumberYesSerum iron. Use the same unit (µg/dL or µmol/L) as TIBC.
tibcnumberYesTotal iron-binding capacity (TIBC), in the same unit as serum iron.
decimalPlacesnumberNo—

Response format

JSON result

JSON
{
  "key": {...},
  "metadata": {
    "key": "value"
  },
  "error": "Error message (optional)",
  "message": "Notification message (optional)"
}

MCP integration

Add this tool to your Model Context Protocol server so AI agents can list and call it.

Server configuration

Add this block to your MCP client configuration:

mcp.json
{
  "mcpServers": {
    "elysiatools-transferrin-saturation": {
      "name": "transferrin-saturation",
      "description": "Calculate Transferrin Saturation (TSAT) = Serum Iron / TIBC × 100% (matching units, µg/dL or µmol/L). Reference range ≈ 20–50% in men and 15–50% in women. TSAT < 20% (or < 15% in premenopausal women) indicates iron deficiency (iron-deficiency anemia from chronic blood loss, inadequate intake, malabsorption), and is highly specific when ferritin is also low. TSAT > 50% (> 45% premenopausal) indicates iron overload or ineffective erythropoiesis: hereditary hemochromatosis, thalassemia major, sideroblastic anemia, repeated transfusions, or excessive iron therapy. Note serum iron has diurnal variation (morning high, evening low) and is shifted by recent iron ingestion, infection/inflammation, and hepatic disease — interpret with ferritin and CRP. Derived from Camaschella Blood 2019, Guyatt 1992, and MDCalc. Not medical advice.",
      "baseUrl": "https://api.elysiatools.com/mcp/sse?toolId=transferrin-saturation",
      "command": "",
      "args": [],
      "env": {},
      "isActive": true,
      "type": "sse"
    }
  }
}

List available tools

After connecting to the SSE endpoint, list the exposed tools:

tools/list
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/list"
}

Call this tool

Invoke the tool by its id, passing arguments built from its parameters:

tools/call
{
  "jsonrpc": "2.0",
  "id": 2,
  "method": "tools/call",
  "params": {
    "name": "transferrin-saturation",
    "arguments": {
  "serumIron": 30,
  "tibc": 420,
  "decimalPlaces": 1
}
  }
}
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© 2026 Elysia Tools. Developer documentation.

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Chain multiple tools in one session with a comma-separated toolId list, e.g. /mcp/sse?toolId=png-to-webp,jpg-to-webp,gif-to-webp (max 20).

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