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Drug Clearance Calculator (CL)

· Last updated：2026-08-02

This tool is for informational purposes only and does not constitute medical, financial, or legal advice; consult a qualified professional for advice.

Calculate drug clearance CL in two modes. (A) Definition: CL = elimination rate / concentration, valid for any pharmacokinetic model. (B) Linear first-order: CL = k · Vd (or derive k from t½ via k = ln2 / t½). Also reports the relationship t½ = 0.693 · Vd / CL. CL is a definitional parameter independent of Vd. Linear mode applies only to first-order elimination — NOT to Michaelis-Menten drugs (phenytoin, high-dose ethanol). Reference: theophylline CL ≈ 2.8 L/h in a 70 kg non-smoking adult. Not medical advice.

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Written by the Elysia Tools team

Tool usage guide

Learn when to use this tool, what it supports, and how real users apply it.

Key facts

Category
Health
Input types
select, number
Output type
json
Sample coverage
4
API ready
Yes

Overview

Calculate drug clearance (CL) from elimination rate and concentration, or from the first-order relationship CL = k · Vd. In linear mode, derive k from half-life when needed and review the related half-life relationship. This calculator is for pharmacokinetic calculations and is not medical advice.

When to use

  • Calculate clearance directly from an elimination rate in mg/h and concentration in mg/L.
  • Estimate clearance in a first-order elimination model using k and volume of distribution.
  • Derive the elimination rate constant from a drug half-life and check the CL–Vd–t½ relationship.

How it works

  1. 1Choose Definition mode to calculate CL = elimination rate ÷ concentration.
  2. 2Choose Linear mode and enter Vd with either k or half-life.
  3. 3When half-life is provided, the calculator derives k using k = ln2 ÷ t½, then calculates CL = k · Vd.
  4. 4The JSON result reports clearance in L/h and, in linear mode, the calculated k and half-life relationship.

Use cases

  • Pharmacokinetics coursework involving clearance, half-life, k, and Vd.
  • Checking a direct clearance calculation from measured elimination rate and concentration.
  • Comparing clearance estimates from first-order half-life and volume-of-distribution data.

Examples

1. Direct clearance from elimination rate and concentration

Pharmacokinetics student

Background

A student needs to calculate clearance from an elimination rate of 14 mg/h and a concentration of 5 mg/L.

Problem

Find CL using the definition that applies to any pharmacokinetic model.

How to use

Select Definition mode, enter 14 for elimination rate, enter 5 for concentration, and leave decimal places at 4.

mode: definition; eliminationRate: 14 mg/h; concentration: 5 mg/L; decimalPlaces: 4

Outcome

The calculator returns CL = 2.8 L/h using 14 ÷ 5.

2. First-order clearance from half-life and Vd

Pharmacokinetics analyst

Background

An analyst has a half-life of 8 hours and a volume of distribution of 31.5 L for a first-order elimination model.

Problem

Calculate k and use it to derive clearance without entering k directly.

How to use

Select Linear mode, enter 8 for half-life, enter 31.5 for Vd, and set decimal places to 4.

FAQ

What is drug clearance?

Clearance is the apparent volume of plasma or blood cleared of drug per unit time, reported here in L/h.

Which inputs are required in Definition mode?

Enter elimination rate in mg/h and concentration in mg/L.

Which inputs are required in Linear mode?

Enter volume of distribution in liters and either k in h⁻¹ or half-life in hours.

Can I use both k and half-life?

The calculator can use half-life to derive k; linear mode is based on first-order elimination.

Does linear mode apply to every drug?

No. Linear mode applies only to first-order elimination, not to Michaelis–Menten drugs such as phenytoin or high-dose ethanol.

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mode: linear; halfLife: 8 h; vd: 31.5 L; decimalPlaces: 4

Outcome

The calculator derives k ≈ 0.0866 h⁻¹ and returns CL = 2.7288 L/h, with a half-life consistency relationship of approximately 8 hours.