What is drug clearance?

Clearance is the apparent volume of plasma or blood cleared of drug per unit time, reported here in L/h.

Which inputs are required in Definition mode?

Enter elimination rate in mg/h and concentration in mg/L.

Which inputs are required in Linear mode?

Enter volume of distribution in liters and either k in h⁻¹ or half-life in hours.

Can I use both k and half-life?

The calculator can use half-life to derive k; linear mode is based on first-order elimination.

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Drug Clearance Calculator (CL)

Calculate drug clearance CL in two modes. (A) Definition: CL = elimination rate / concentration, valid for any pharmacokinetic model. (B) Linear first-order: CL = k · Vd (or derive k from t½ via k = ln2 / t½). Also reports the relationship t½ = 0.693 · Vd / CL. CL is a definitional parameter independent of Vd. Linear mode applies only to first-order elimination — NOT to Michaelis-Menten drugs (phenytoin, high-dose ethanol). Reference: theophylline CL ≈ 2.8 L/h in a 70 kg non-smoking adult. Not medical advice.

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2 examples

Definition mode: rate 14 mg/h, C 5 mg/L → CL = 2.8 L/h

CL = 14 / 5 = 2.8 L/h. Matches typical theophylline clearance in a 70 kg non-smoking adult.

{"result":"CL = 2.8 L/h (definition: elimination rate 14 mg/h ÷ C 5 mg/L).","metadata":{"input":{"mode":"definition","eliminationRate":14,"concentration":5},"result":{"clearance":2.8,"clearanceUnit":"L/h","method":"Definition: CL = rate / C","model":"Definitional — applies to any pharmacokinetic model. Not medical advice."}}}

Linear mode: Vd=31.5 L, t½=8 h → CL = 2.7373 L/h

k = ln2/8 = 0.0866 h⁻¹; CL = k·Vd = 0.0866 × 31.5 = 2.7288 L/h. Same drug, derived from Vd and t½.

{"result":"CL = 2.7288 L/h (linear: k = 0.0866 h⁻¹ × Vd 31.5 L). t½ consistency: 0.693·31.5/2.7288 = 8 h.","metadata":{"input":{"mode":"linear","halfLife":8,"vd":31.5},"result":{"clearance":2.7288,"clearanceUnit":"L/h","k":0.0866,"halfLifeDerived":8,"method":"Linear: CL = k · Vd, k = ln2 / t½","model":"Linear first-order elimination. Not medical advice."}}}

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7 options

SettingsAdjust formats, ranges, numbers, and modes.7

Calculation ModeselectOptionalElimination rate (mg/h)numberOptionalMass eliminated per unit time. Required in Definition mode.Concentration C (mg/L)numberOptionalBlood/plasma concentration. Required in Definition mode.Elimination rate constant k (h⁻¹)numberOptionalFirst-order elimination rate constant. Linear mode: provide k OR t½.Half-life t½ (h, alternative to k)numberOptionalOptional half-life; if provided, k = ln2 / t½.Volume of distribution Vd (L)numberOptionalApparent volume of distribution. Required in Linear mode.Decimal PlacesnumberOptional

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Drug Clearance Calculator (CL)

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1. Direct clearance from elimination rate and concentration

2. First-order clearance from half-life and Vd

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