Compute CaO₂ = 1.34×Hb×SaO₂ + 0.003×PaO₂ and (if mixed-venous values supplied) CvO₂, a-v difference, extraction ratio, DO₂, VO₂. Derived from Hüfner 1894, West, StatPearls, LITFL, Leach 2002. Not medical advice.
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Tool usage guide
Learn when to use this tool, what it supports, and how real users apply it.
Key facts
Category
Health
Input types
number
Output type
json
Sample coverage
4
API ready
Yes
Overview
The Blood Oxygen Content Calculator estimates arterial oxygen content (CaO₂) from hemoglobin, arterial oxygen saturation, and PaO₂. When mixed-venous values and cardiac output are provided, it also calculates CvO₂, the arterial–venous oxygen difference, extraction ratio, oxygen delivery (DO₂), and oxygen consumption (VO₂). This calculator is for reference and is not medical advice.
When to use
Estimate arterial oxygen content from hemoglobin, SaO₂, and PaO₂ values.
Compare arterial and mixed-venous oxygen content using SvO₂ and PvO₂.
Calculate oxygen delivery and consumption when cardiac output is available.
How it works
1Enter hemoglobin in g/dL, arterial oxygen saturation as a fraction from 0 to 1, and PaO₂ in mmHg.
2The calculator applies CaO₂ = 1.34 × Hb × SaO₂ + 0.003 × PaO₂ and reports bound, dissolved, and total oxygen.
3Optionally enter SvO₂ and PvO₂ to calculate CvO₂, the a-v oxygen difference, and the extraction ratio.
4Add cardiac output in L/min to calculate DO₂ and VO₂, with results rounded to the selected decimal places.
Use cases
Review arterial oxygen content when assessing the effects of hemoglobin, saturation, and PaO₂.
Study oxygen extraction by comparing CaO₂ with CvO₂ from mixed-venous measurements.
Estimate oxygen delivery and consumption for critical care calculations when cardiac output is known.
Examples
1. Normal arterial oxygen content
Medical student
Background
A student wants to verify the contribution of hemoglobin-bound and dissolved oxygen in a typical arterial blood sample.
Problem
Calculate CaO₂ from Hb 15 g/dL, SaO₂ 0.97, and PaO₂ 100 mmHg.
How to use
Enter 15 for hemoglobin, 0.97 for SaO₂, 100 for PaO₂, and select 2 decimal places.
The calculator returns CaO₂ ≈ 14.97 mL/dL, CvO₂ ≈ 11.36 mL/dL, an a-v difference of 3.61 mL/dL, an extraction ratio of 0.24, DO₂ ≈ 673.81 mL/min, and VO₂ ≈ 162.57 mL/min.