What inputs are required?

Enter counts for AA, Aa, and aa. Decimal places are optional and default to 4.

What does N represent?

N is the total sample count: AA count + Aa count + aa count.

How are genotype frequencies calculated?

Each genotype frequency equals its observed count divided by N.

What do p and q represent?

p and q are the calculated frequencies of the two alleles at the biallelic locus.

Can this calculator be used for medical diagnosis?

No. It is provided for educational use only.

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Genotype Frequency Calculator

Compute genotype frequencies from counts: freq = count / N. Also derives allele and phenotypic frequencies. Derived from Hartl & Clark 2007, Griffiths, StatPearls. Educational use only.

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2 examples

Standard sample: 50 AA, 30 Aa, 20 aa → frequencies sum to 1

N = 100. Genotype frequencies: AA = 0.50, Aa = 0.30, aa = 0.20. Allele frequencies: p = 0.50 + 0.15 = 0.65, q = 0.20 + 0.15 = 0.35. Under complete dominance: dominant phenotype = 80%, recessive = 20%.

{"result":"N=100: AA=0.5, Aa=0.3, aa=0.2.","metadata":{"input":{"AA":50,"Aa":30,"aa":20},"result":{"N":100,"freqAA":0.5,"freqAa":0.3,"freqaa":0.2,"p":0.65,"q":0.35,"dominantPhenotype":0.8,"recessivePhenotype":0.2}}}

Disease alleles: 64 AA, 32 Aa, 4 aa → p = 0.80, q = 0.20

N = 100. Genotype frequencies: AA = 0.64, Aa = 0.32, aa = 0.04. Allele frequencies: p = 0.64 + 0.16 = 0.80, q = 0.04 + 0.16 = 0.20. If aa is a recessive disease genotype, the disease frequency is 4% and the carrier frequency is 32%.

{"result":"N=100: AA=0.64, Aa=0.32, aa=0.04.","metadata":{"input":{"AA":64,"Aa":32,"aa":4},"result":{"N":100,"freqAA":0.64,"freqAa":0.32,"freqaa":0.04,"p":0.8,"q":0.2,"dominantPhenotype":0.96,"recessivePhenotype":0.04}}}

Inputs

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4 options

SettingsAdjust formats, ranges, numbers, and modes.4

AA count (homozygous dominant)numberRequiredObserved count of genotype AA.Aa count (heterozygous)numberRequiredObserved count of genotype Aa.aa count (homozygous recessive)numberRequiredObserved count of genotype aa.Decimal PlacesnumberOptional

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Genotype Frequency Calculator

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Examples

1. Standard population sample

2. Recessive disease genotype example

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