Health
Categorize renal function from creatinine clearance (CrCl) and provide FDA/KDIGO-aligned dosing guidance: Normal (CrCl ≥60) → standard dosing; Mild (30–59) → consider dose reduction or interval extension; Moderate (15–29) → reduction and/or extension typically required; Severe (<15) → significant reduction, many drugs contraindicated or post-dialysis only. Outlines two adjustment strategies: (A) interval extension for concentration-dependent drugs (aminoglycosides, vancomycin), (B) dose reduction for time-dependent drugs (β-lactams). Dialysis toggle flags the need for post-dialysis supplementation per the specific drug label. Derived from FDA Pharmacokinetics Guidance, the KDIGO Drug Dosing Consensus, and NIDDK guidance. This tool does NOT replace the FDA-approved package insert for any specific drug. Not medical advice.
Call this tool from your code in three languages.
curl -X POST 'https://api.elysiatools.com/en/api/tools/renal-dose-adjustment' \
-H 'Content-Type: application/json' \
-d '{"crcl":45,"onDialysis":false,"decimalPlaces":4}'Send a POST request with your inputs as JSON. File parameters require a separate upload first.
POST https://api.elysiatools.com/en/api/tools/renal-dose-adjustment| Name | Type | Required | Description |
|---|---|---|---|
| crcl | number | Yes | Estimated creatinine clearance in mL/min (Cockcroft-Gault is standard for drug labeling). Must be ≥0. |
| onDialysis | checkbox | No | If checked, flags that renally cleared drugs often need post-dialysis supplementation per the specific drug label. |
| decimalPlaces | number | No | — |
JSON result
{
"key": {...},
"metadata": {
"key": "value"
},
"error": "Error message (optional)",
"message": "Notification message (optional)"
}Add this tool to your Model Context Protocol server so AI agents can list and call it.
Add this block to your MCP client configuration:
{
"mcpServers": {
"elysiatools-renal-dose-adjustment": {
"name": "renal-dose-adjustment",
"description": "Categorize renal function from creatinine clearance (CrCl) and provide FDA/KDIGO-aligned dosing guidance: Normal (CrCl ≥60) → standard dosing; Mild (30–59) → consider dose reduction or interval extension; Moderate (15–29) → reduction and/or extension typically required; Severe (<15) → significant reduction, many drugs contraindicated or post-dialysis only. Outlines two adjustment strategies: (A) interval extension for concentration-dependent drugs (aminoglycosides, vancomycin), (B) dose reduction for time-dependent drugs (β-lactams). Dialysis toggle flags the need for post-dialysis supplementation per the specific drug label. Derived from FDA Pharmacokinetics Guidance, the KDIGO Drug Dosing Consensus, and NIDDK guidance. This tool does NOT replace the FDA-approved package insert for any specific drug. Not medical advice.",
"baseUrl": "https://api.elysiatools.com/mcp/sse?toolId=renal-dose-adjustment",
"command": "",
"args": [],
"env": {},
"isActive": true,
"type": "sse"
}
}
}After connecting to the SSE endpoint, list the exposed tools:
{
"jsonrpc": "2.0",
"id": 1,
"method": "tools/list"
}Invoke the tool by its id, passing arguments built from its parameters:
{
"jsonrpc": "2.0",
"id": 2,
"method": "tools/call",
"params": {
"name": "renal-dose-adjustment",
"arguments": {
"crcl": 45,
"onDialysis": false,
"decimalPlaces": 4
}
}
}Questions or issues? Contact [email protected]