Health

Maintenance Dose Calculator (MD = Css · CL · τ / F)

Calculate the maintenance dose that holds the average steady-state concentration at a target value: MD = Css,avg · CL · τ / F, where Css,avg is the target average concentration, CL is clearance, τ is the dosing interval, and F is bioavailability (1 for IV, <1 for oral). Derived from steady-state mass balance (rate in = rate out): the dose per interval equals the amount cleared over one interval, corrected for bioavailability. Targets the AVERAGE Css,avg — the peak Cmax,ss and trough Cmin,ss fluctuate around it depending on t½ and τ. Valid only for linear pharmacokinetics with fixed dose and interval — NOT for Michaelis-Menten drugs (phenytoin). Optional body-weight input converts the result to mg/kg. Not medical advice.

json· JSON resultOpen tool

Quick start

Call this tool from your code in three languages.

cURL

curl -X POST 'https://api.elysiatools.com/en/api/tools/maintenance-dose-calculator' \
  -H 'Content-Type: application/json' \
  -d '{"css":10,"clearance":2.8,"interval":12,"bioavailability":0.9,"weight":70,"decimalPlaces":4}'

API reference

Send a POST request with your inputs as JSON. File parameters require a separate upload first.

Endpoint

HTTP

POST https://api.elysiatools.com/en/api/tools/maintenance-dose-calculator

Parameters

Name	Type	Required	Description
css	number	Yes	Target average steady-state concentration. Must be positive.
clearance	number	Yes	Drug clearance in L/h. Must be positive.
interval	number	Yes	Time between consecutive doses in hours. Must be positive.
bioavailability	number	Yes	Fraction of dose reaching systemic circulation. IV=1, oral<1. Range (0, 1].
weight	number	No

MCP integration

Add this tool to your Model Context Protocol server so AI agents can list and call it.

Server configuration

Add this block to your MCP client configuration:

mcp.json

{
  "mcpServers": {
    "elysiatools-maintenance-dose-calculator": {
      "name": "maintenance-dose-calculator",
      "description": "Calculate the maintenance dose that holds the average steady-state concentration at a target value: MD = Css,avg · CL · τ / F, where Css,avg is the target average concentration, CL is clearance, τ is the dosing interval, and F is bioavailability (1 for IV, <1 for oral). Derived from steady-state mass balance (rate in = rate out): the dose per interval equals the amount cleared over one interval, corrected for bioavailability. Targets the AVERAGE Css,avg — the peak Cmax,ss and trough Cmin,ss fluctuate around it depending on t½ and τ. Valid only for linear pharmacokinetics with fixed dose and interval — NOT for Michaelis-Menten drugs (phenytoin). Optional body-weight input converts the result to mg/kg. Not medical advice.",
      "baseUrl": "https://api.elysiatools.com/mcp/sse?toolId=maintenance-dose-calculator",
      "command": "",
      "args": [],
      "env": {},
      "isActive": true,
      "type": "sse"
    }
  }
}

List available tools

After connecting to the SSE endpoint, list the exposed tools:

tools/list

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/list"
}

Call this tool

Invoke the tool by its id, passing arguments built from its parameters:

tools/call

{
  "jsonrpc": "2.0",
  "id": 2,
  "method": "tools/call",
  "params": {
    "name": "maintenance-dose-calculator",
    "arguments": {
  "css": 10,
  "clearance": 2.8,
  "interval": 12,
  "bioavailability": 0.9,
  "weight": 70,
  "decimalPlaces": 4
}
  }
}

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