Health

LDL-C Calculator (Friedewald)

Calculate LDL-C (low-density lipoprotein cholesterol) indirectly with the Friedewald formula. In mg/dL: LDL-C = Total Cholesterol − HDL-C − (Triglycerides / 5); in mmol/L: LDL-C = TC − HDL-C − (TG / 2.2). Unreliable when triglycerides ≥ 400 mg/dL (4.5 mmol/L), in the non-fasting state, in type III dysbetalipoproteinemia, and at very low LDL-C (< 70 mg/dL). Treatment thresholds (ACC/AHA 2018): < 70 mg/dL (1.8 mmol/L) high-risk secondary prevention; < 100 mg/dL (2.6 mmol/L) moderate-risk / diabetes primary prevention; ≥ 190 mg/dL (4.9 mmol/L) suggests familial hypercholesterolemia. Unit system selectable: mg/dL or mmol/L. Derived from Friedewald 1972, Martin 2013, Sampson 2020, and ACC/AHA 2018. Not medical advice.

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Quick start

Call this tool from your code in three languages.

cURL

curl -X POST 'https://api.elysiatools.com/en/api/tools/ldl-calculator-friedewald' \
  -H 'Content-Type: application/json' \
  -d '{"unitSystem":"mgdl","totalCholesterol":220,"hdl":45,"triglycerides":150,"decimalPlaces":1}'

API reference

Send a POST request with your inputs as JSON. File parameters require a separate upload first.

Endpoint

HTTP

POST https://api.elysiatools.com/en/api/tools/ldl-calculator-friedewald

Parameters

Name	Type	Required	Description
unitSystem	select	Yes	—
totalCholesterol	number	Yes	Fasting total cholesterol. Use the unit selected under 'Unit System'.
hdl	number	Yes	Fasting HDL-C. Use the unit selected under 'Unit System'.
triglycerides	number	Yes	Fasting triglycerides. Use the unit selected under 'Unit System'. Note: Friedewald is unreliable when TG ≥ 400 mg/dL (4.5 mmol/L).
decimalPlaces	number

MCP integration

Add this tool to your Model Context Protocol server so AI agents can list and call it.

Server configuration

Add this block to your MCP client configuration:

mcp.json

{
  "mcpServers": {
    "elysiatools-ldl-calculator-friedewald": {
      "name": "ldl-calculator-friedewald",
      "description": "Calculate LDL-C (low-density lipoprotein cholesterol) indirectly with the Friedewald formula. In mg/dL: LDL-C = Total Cholesterol − HDL-C − (Triglycerides / 5); in mmol/L: LDL-C = TC − HDL-C − (TG / 2.2). Unreliable when triglycerides ≥ 400 mg/dL (4.5 mmol/L), in the non-fasting state, in type III dysbetalipoproteinemia, and at very low LDL-C (< 70 mg/dL). Treatment thresholds (ACC/AHA 2018): < 70 mg/dL (1.8 mmol/L) high-risk secondary prevention; < 100 mg/dL (2.6 mmol/L) moderate-risk / diabetes primary prevention; ≥ 190 mg/dL (4.9 mmol/L) suggests familial hypercholesterolemia. Unit system selectable: mg/dL or mmol/L. Derived from Friedewald 1972, Martin 2013, Sampson 2020, and ACC/AHA 2018. Not medical advice.",
      "baseUrl": "https://api.elysiatools.com/mcp/sse?toolId=ldl-calculator-friedewald",
      "command": "",
      "args": [],
      "env": {},
      "isActive": true,
      "type": "sse"
    }
  }
}

List available tools

After connecting to the SSE endpoint, list the exposed tools:

tools/list

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/list"
}

Call this tool

Invoke the tool by its id, passing arguments built from its parameters:

tools/call

{
  "jsonrpc": "2.0",
  "id": 2,
  "method": "tools/call",
  "params": {
    "name": "ldl-calculator-friedewald",
    "arguments": {
  "unitSystem": "mgdl",
  "totalCholesterol": 220,
  "hdl": 45,
  "triglycerides": 150,
  "decimalPlaces": 1
}
  }
}

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