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Autosomal Recessive Inheritance Risk Calculator

Compute per-child and cumulative autosomal recessive disease risk from parental statuses (carrier / affected / non-carrier / unknown via population carrier rate), including the 2/3 carrier rule. Derived from Griffiths, Hartl & Clark 2007, StatPearls. Educational use only.

json· JSON resultOpen tool

Quick start

Call this tool from your code in three languages.

cURL
curl -X POST 'https://api.elysiatools.com/en/api/tools/autosomal-recessive-risk' \
  -H 'Content-Type: application/json' \
  -d '{"parent1Status":"carrier","parent2Status":"carrier","carrierRate":0.04,"childCount":2,"decimalPlaces":4}'

API reference

Send a POST request with your inputs as JSON. File parameters require a separate upload first.

Endpoint

HTTP
POST https://api.elysiatools.com/en/api/tools/autosomal-recessive-risk

Parameters

NameTypeRequiredDescription
parent1StatusselectYesGenotype status of the first parent.
parent2StatusselectYesGenotype status of the second parent.
carrierRatenumberYesPopulation carrier frequency c used when a parent's status is unknown (P(Aa) = c, P(aa) = c²).
childCountnumberYesNumber of children for the cumulative at-least-one-affected risk.
decimalPlacesnumber

MCP integration

Add this tool to your Model Context Protocol server so AI agents can list and call it.

Server configuration

Add this block to your MCP client configuration:

mcp.json
{
  "mcpServers": {
    "elysiatools-autosomal-recessive-risk": {
      "name": "autosomal-recessive-risk",
      "description": "Compute per-child and cumulative autosomal recessive disease risk from parental statuses (carrier / affected / non-carrier / unknown via population carrier rate), including the 2/3 carrier rule. Derived from Griffiths, Hartl & Clark 2007, StatPearls. Educational use only.",
      "baseUrl": "https://api.elysiatools.com/mcp/sse?toolId=autosomal-recessive-risk",
      "command": "",
      "args": [],
      "env": {},
      "isActive": true,
      "type": "sse"
    }
  }
}

List available tools

After connecting to the SSE endpoint, list the exposed tools:

tools/list
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/list"
}

Call this tool

Invoke the tool by its id, passing arguments built from its parameters:

tools/call
{
  "jsonrpc": "2.0",
  "id": 2,
  "method": "tools/call",
  "params": {
    "name": "autosomal-recessive-risk",
    "arguments": {
  "parent1Status": "carrier",
  "parent2Status": "carrier",
  "carrierRate": 0.04,
  "childCount": 2,
  "decimalPlaces": 4
}
  }
}
Chain multiple tools in one session with a comma-separated toolId list, e.g. /mcp/sse?toolId=png-to-webp,jpg-to-webp,gif-to-webp (max 20).
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Response format

JSON result

JSON
{
  "key": {...},
  "metadata": {
    "key": "value"
  },
  "error": "Error message (optional)",
  "message": "Notification message (optional)"
}

Questions or issues? Contact [email protected]