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Autosomal Dominant Pedigree Analyzer

Compute AD offspring risk (Aa×aa 1:1, Aa×Aa 3:1, AA×any all affected), chi-square fit of observed children, and hallmark checks including male-to-male transmission that rules out X-linked dominant. Derived from Griffiths, Hartl & Clark 2007, StatPearls, OMIM. Educational use only.

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Quick start

Call this tool from your code in three languages.

cURL
curl -X POST 'https://api.elysiatools.com/en/api/tools/autosomal-dominant-pedigree' \
  -H 'Content-Type: application/json' \
  -d '{"parent1Status":"affected-heterozygous","parent2Status":"unaffected","affectedChildren":8,"unaffectedChildren":7,"maleToMaleTransmission":true,"decimalPlaces":4}'

API reference

Send a POST request with your inputs as JSON. File parameters require a separate upload first.

Endpoint

HTTP
POST https://api.elysiatools.com/en/api/tools/autosomal-dominant-pedigree

Parameters

NameTypeRequiredDescription
parent1StatusselectYesGenotype status of the first parent.
parent2StatusselectYesGenotype status of the second parent.
affectedChildrennumberYesNumber of affected children observed in the sibship.
unaffectedChildrennumberYesNumber of unaffected children observed in the sibship.
maleToMaleTransmissioncheckbox

MCP integration

Add this tool to your Model Context Protocol server so AI agents can list and call it.

Server configuration

Add this block to your MCP client configuration:

mcp.json
{
  "mcpServers": {
    "elysiatools-autosomal-dominant-pedigree": {
      "name": "autosomal-dominant-pedigree",
      "description": "Compute AD offspring risk (Aa×aa 1:1, Aa×Aa 3:1, AA×any all affected), chi-square fit of observed children, and hallmark checks including male-to-male transmission that rules out X-linked dominant. Derived from Griffiths, Hartl & Clark 2007, StatPearls, OMIM. Educational use only.",
      "baseUrl": "https://api.elysiatools.com/mcp/sse?toolId=autosomal-dominant-pedigree",
      "command": "",
      "args": [],
      "env": {},
      "isActive": true,
      "type": "sse"
    }
  }
}

List available tools

After connecting to the SSE endpoint, list the exposed tools:

tools/list
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/list"
}

Call this tool

Invoke the tool by its id, passing arguments built from its parameters:

tools/call
{
  "jsonrpc": "2.0",
  "id": 2,
  "method": "tools/call",
  "params": {
    "name": "autosomal-dominant-pedigree",
    "arguments": {
  "parent1Status": "affected-heterozygous",
  "parent2Status": "unaffected",
  "affectedChildren": 8,
  "unaffectedChildren": 7,
  "maleToMaleTransmission": true,
  "decimalPlaces": 4
}
  }
}
Chain multiple tools in one session with a comma-separated toolId list, e.g. /mcp/sse?toolId=png-to-webp,jpg-to-webp,gif-to-webp (max 20).
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No
Whether an affected father has an affected son (rules out X-linked dominant inheritance).
decimalPlacesnumberNo—

Response format

JSON result

JSON
{
  "key": {...},
  "metadata": {
    "key": "value"
  },
  "error": "Error message (optional)",
  "message": "Notification message (optional)"
}

Questions or issues? Contact [email protected]