# Goodwin 振荡器 — 昼夜节律基因钟

一个三基因负反馈回路驱动 24 小时生物钟。调节 Hill 系数 n——当 n 低于阈值约 8 时振荡消失，揭示了为什么昼夜节律钟需要高度协同的基因调控。

> 标准页面: https://elysiatools.com/zh/visualizations/goodwin-oscillator

- **分类:** Biology

## 概述

Interactive Goodwin oscillator (circadian gene clock) visualization. A three-gene negative-feedback loop — mRNA (X) → protein (Y) → repressor (Z) → inhibits X transcription — produces sustained ~24-hour oscillations through delayed negative feedback. The three coupled ODEs: dX/dt = a/(1+Zⁿ) − bX (Hill-repressed transcription), dY/dt = cX − bY (translation), dZ/dt = cY − bZ (repressor maturation), integrated with RK4. The central biological insight: linear stability (Routh-Hurwitz) analysis of the unique fixed point shows sustained oscillation requires the Hill coefficient n to exceed a critical value n_crit≈8 — below that the feedback is too gentle to overcome damping and the cell is arrhythmic. This explains why real circadian clocks need highly cooperative (switch-like) gene regulation via multimerization and multi-site binding. Three visualization panels: (1) Scrolling mRNA/Protein/Repressor time series (X blue, Y green, Z red) showing the three gene products cycling out of phase with the characteristic negative-feedback delay, with dashed fixed-point reference lines. (2) Phase portrait in the X-Y plane showing the trajectory converging to a closed limit cycle above threshold vs spiraling into the fixed point below threshold, with the fixed point marked and regime banner. (3) Bifurcation panel sweeping n from 1→12 and plotting oscillation amplitude — the Hopf bifurcation at n_crit≈8 is marked where amplitude jumps from zero (red/steady) to nonzero (green/oscillating), the mathematical signature of the cooperativity requirement. Adjustable parameters: Hill coefficient n (1–12), transcription rate a (0.5–4), degradation rate b (0.1–1, sets period), translation rate c (0.3–2). Five scenario presets: Healthy Clock (n=9, clean oscillation), Low Cooperation (n=4, dead arrhythmic clock), At Threshold (n=8, Hopf bifurcation), Fast Clock (high n + fast decay, short-period mutant), Strong Output (high transcription, large amplitude). Real-time statistics: regime (Oscillating/Steady/Marginal), oscillation period, critical Hill coefficient n_crit, and amplitude. Educational content covers the negative-feedback loop mechanism (Goodwin 1965), the Routh-Hurwitz n>8 threshold and why real clocks need cooperativity, and real circadian biology (mammalian CLOCK/BMAL1↔PER/CRY loop, CK1δ/ε period tuning and Familial Advanced Sleep Phase Syndrome, Drosophila PER/TIM, fungal FRQ/WC-1, cyanobacterial KaiABC, jet lag and shift-work re-phasing). Multi-language support (zh, en, es, fr, de, ru, pt).

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