# Dialysis Dose Kt/V Calculator (Daugirdas 2nd Gen.) Estimate single-pool Kt/V (spKt/V) for a hemodialysis session with the Daugirdas second-generation formula: Kt/V = −ln(R − 0.008·t) + (4 − 3.5·R) × UF / W, where R = Post-BUN/Pre-BUN, t = treatment time (h), UF = ultrafiltration volume (kg), W = post-dialysis weight (kg). The first term captures urea removal and generation; the second corrects for volume contraction. KDOQI target: spKt/V ≥1.2 per session (minimum delivered dose) for conventional thrice-weekly hemodialysis, target ~1.4. Requires post-dialysis BUN drawn by slow-flow/stop-pump technique. Derived from Daugirdas JT, J Am Soc Nephrol 1993. Valid for intermittent hemodialysis; not for peritoneal dialysis or CRRT/SLED. Not medical advice. > Canonical page: https://elysiatools.com/en/tools/kt-v-dialysis-dose - **Category:** Health - **Keywords:** Kt/V, spKt/V, dialysis dose, Daugirdas, hemodialysis adequacy, BUN, ultrafiltration, KDOQI, nephrology, renal, urea kinetic modeling ## Overview Estimate single-pool Kt/V (spKt/V) for an intermittent hemodialysis session using the Daugirdas second-generation formula. Enter pre- and post-dialysis BUN, treatment time, ultrafiltration volume, and post-dialysis weight to receive the Kt/V value, BUN ratio, and a status against the 1.2 minimum reference. ## Inputs - **Pre-dialysis BUN (mg/dL)** (number): Pre-dialysis blood urea nitrogen in mg/dL. Must be positive. - **Post-dialysis BUN (mg/dL)** (number): Post-dialysis blood urea nitrogen in mg/dL (slow-flow technique). Must be positive and less than pre-BUN. - **Treatment time (hours)** (number): Dialysis treatment time in hours. Must be positive. - **Ultrafiltration volume UF (kg)** (number): Intradialytic weight loss (ultrafiltration volume) in kg. Must be ≥0. - **Post-dialysis weight W (kg)** (number): Post-dialysis body weight in kg. Must be positive. - **Decimal Places** (number) ## When to use - Estimate delivered dialysis dose for a conventional intermittent hemodialysis session. - Review how BUN reduction, treatment time, ultrafiltration, and post-dialysis weight affect spKt/V. - Check whether a calculated session reaches the KDOQI minimum reference of 1.2. ## How it works - Enter positive pre-dialysis and post-dialysis BUN values, with post-dialysis BUN lower than pre-dialysis BUN. - Enter treatment time in hours, ultrafiltration volume in kilograms, and post-dialysis weight in kilograms. - The calculator computes R as post-dialysis BUN divided by pre-dialysis BUN and applies the Daugirdas second-generation formula. - The JSON result includes Kt/V, ratio R, status, method, and a note about the 1.2 minimum reference. ## Use cases - Nephrology teams can estimate the delivered spKt/V for individual hemodialysis sessions. - Dialysis educators can demonstrate the relationship between BUN values, treatment time, ultrafiltration, and post-dialysis weight. - Clinical reviewers can compare calculated results with the KDOQI minimum reference and target range. ## Frequently asked questions ### What does this calculator estimate? It estimates single-pool Kt/V (spKt/V) for an intermittent hemodialysis session. ### Which formula does it use? It uses the Daugirdas second-generation formula: −ln(R − 0.008·t) + (4 − 3.5·R)·UF/W. ### What inputs are required? Pre- and post-dialysis BUN, treatment time, ultrafiltration volume, and post-dialysis weight are required. ### How should post-dialysis BUN be collected? Use a slow-flow or stop-pump collection technique, as specified in the tool description. ### Does this calculator apply to peritoneal dialysis or CRRT? No. It is intended for intermittent hemodialysis and not for peritoneal dialysis, CRRT, or SLED. ## Related tools - [eGFR Calculator (CKD-EPI 2021 Race-Free)](https://elysiatools.com/en/tools/egfr-ckd-epi): Estimate glomerular filtration rate (eGFR) with the CKD-EPI 2021 race-free creatinine equation: eGFR = 142 × min(SCr/κ, 1)^α × max(SCr/κ, 1)^(−1.200) × 0.9938^Age × 1.012 if female, where κ = 0.7 (female) / 0.9 (male) and α = −0.241 (female) / −0.302 (male). 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